For best performance of After Effects within a Enterprise Workstation please follow these optimizations:
1. Make sure to clean your cache as often as possible.
*The Enterprise Workstation Dashboard has a purge function included.
2. Set your disk cache to external storage.
3. Update cache size to 128GB if you have enough storage.
4. Enable untested, unsupported GPU for CUDA acceleration:
Select the "Previews" button on the left of preferences then select the "GPU Information" Button.
Activate "Enable untested, unsupported GPU for CUDA acceleration..."